国产精品美女一区二区三区-国产精品美女自在线观看免费-国产精品秘麻豆果-国产精品秘麻豆免费版-国产精品秘麻豆免费版下载-国产精品秘入口

Set as Homepage - Add to Favorites

【phim m? c?p 3】Enter to watch online.3 scientists win Nobel Prize in medicine for biological clock research

Source： Editor：recreation Time：2025-07-05 15:35:23

The phim m? c?p 32017 Nobel Prize in Physiology or Medicine was awarded on Monday morning to Jeffrey Hall, Michael Rosbash, and Michael Young for their discoveries of the molecular underpinnings of the circadian rhythms that help organisms adapt to our 24-hour days.

The scientists “were able to peek inside our biological clock and elucidate its inner workings,” said Thomas Perlmann, Secretary of the Nobel Committee for Physiology or Medicine, who announced the prize in Stockholm. “Their discoveries explain how plants, animals, and humans adapt their biological rhythm so that it is synchronized with the Earth’s revolutions.”

SEE ALSO: Google Doodle honours Australia's only Nobel Prize winner in chemistry

Hall, of Brandeis University; Rosbash, also of Brandeis; and Young, of Rockefeller University, will share a prize of 9 million Swedish krona, or about $940,000.

When Perlmann called Rosbash, the newly minted laureate was initially silent, and then said, “You are kidding me.”

As far back as the 1970s, scientists asked whether it would be possible to identify genes that control the daily rhythm of metabolism, sleeping and waking, and other basic processes in fruit flies. They found that mutations in an unknown gene disrupted flies’ circadian clock and named the gene “period,” or per.

Mashable Trend Report Decode what’s viral, what’s next, and what it all means. Sign up for Mashable’s weekly Trend Report newsletter. By clicking Sign Me Up, you confirm you are 16+ and agree to our Terms of Use and Privacy Policy. Thanks for signing up!

In the 1980s Hall and Rosbash, working at Brandeis, and, separately, Young at Rockefeller isolated the circadian rhythm genes. Hall and Rosbash then discovered that levels of the protein the gene makes, dubbed PER, build up during the night and drop during the day, oscillating over a 24-hour cycle. The gene Young found in 1994, called timeless, makes a protein named TIM that was also required for a normal circadian rhythm.

Mashable Image(L-R) Jeffrey C. Hall, Michael Rosbash and Michael W. Young Winners of the 2017 Nobel Prize in Physiology or Medicine. Credit: JONAS EKSTROMER/EPA-EFE/REX/Shutterstock

The “paradigm-shifting discoveries,” as the Nobel citation called them, were that the proteins enter the cell nucleus, where its genes reside, and turn off the DNA that had been busy making them. In other words, the build-up of the protein causes the production of the protein to shut down, in one of nature’s more elegant negative feedback loops.

People’s circadian rhythms are controlled much as flies’ are, with gene expression cycling through a 24-hour (or so) period. “Since the seminal discoveries by the three laureates, circadian biology has developed into a vast and highly dynamic research field, with implications for our health and wellbeing,” the Nobel citation said.

Jeremy Berg, editor-in-chief of Science and former director of the National Institute of General Medical Sciences, called the laureates’ work “very elegant and fundamental.” Before their discoveries, he said, “the nature of the circadian clock was a great mystery. Through genetics and the emerging tools of molecular biology, a very elegant molecular pathway was sorted out involving a feedback loop where a protein controls its own expression.”

One of the surprises of this work, Berg said, is that the circadian clock operates in essentially all cells that contain a nucleus, not only specialized cells in the brain, allowing PER and TIM to “affect other aspects of physiology” with “implications for work schedules, sleep hygiene,” and more, ushering in the field of chronobiology.

Featured Video For You
The disturbing truth about vitamins

0.2603s , 10188.6953125 kb

Copyright © 2025 Powered by 【phim m? c?p 3】Enter to watch online.3 scientists win Nobel Prize in medicine for biological clock research,  

Sitemap

Top 主站蜘蛛池模板： 动漫精品偷拍日韩 | 午夜无码片在线观看线 | 一区二区三区国产精华液 | 午夜电影院理论电影院 | 99国产婷婷综合在线视频 | 国产av毛片久 | 91在线超高颜值国产 | A片人人澡C片人人人妻付费 | 波多野结av衣东京热 | av潮喷大喷水系列无码 | 丰满人妻熟妇乱偷人无码 | 丰满人妻熟妇乱又伦精品视频三 | 丰满老熟好大bbb | 果冻传媒91制片厂 | 丰满肥女巨肥bw | 91在线无码精品国产三年 | 99精品欧美一区 | 一区二区三区欧美 | 高潮呻吟久久av无码 | 91久久精品国产一区二区九色 | AV每日更新在线观看 | 午夜福利日韩在线 | 东京热无码专区 | 成人激情在线 | 午夜成年人网站 | 91字幕| 一区二区三区导航 | 99精品久久久久久久免费看蜜月 | 91福利免费体 | 一区二区三区视频免费在线观看 | 东京热久久精品视频 | WWW.亚洲最大夜色伊人 | 91精品国产福利尤物 | 成人dvd碟片| 91天堂在线视频 | 午夜性色在线观看视频 | 97色精品 | 99久久国产免费福利 | 91黄色视频免费精品入口 | 国产av激 | 日韩av在线网 |